Uses of Zocor

ZOCOR is a prescription drug that is indicated as an addition to diet for many patients with high cholesterol when diet and exercise are inadequate. For patients with coronary heart disease (CHD) and high cholesterol, ZOCOR is indicated as an addition to diet to reduce the risk of death by reducing coronary death; to reduce the risk of heart attack; to reduce the risk for undergoing cardiac procedures (coronary artery bypass grafting and percutaneous transluminal coronary angioplasty); and to reduce the risk of stroke or transient ischemic attack (TIA).

Wednesday, October 24, 2007

Simvastatin

Simvastatin - the basis for CYP3A4 (PRECAUTIONS see, PREPARATION INTERACTIONS). Grapefruit juice contains one or more components which forbid CYP3A4 and can increase, plasma concentration of drugs got CYP3A4. In one study2 10 subjects consumed 200 ml of juice of a grapefruit of double force (all can the frozen concentrate terminated with one instead of 3 canisters of water), three times daily within 2 days and additional juice of a grapefruit of double force on 200 ml together with, and later 30 and 90 minutes after that, a unique dose of 60 mg simvastatin for the third day. This way of juice of a grapefruit has led to greedy increases in concentration (as it is measured by area at unique concentration of a curve), active and full reduktazy HMG-CoA activity prohibition [measured use radioenzyme estimates both prohibitions before (for active ingibitorov) and after (for full ingibitorov) the basic hydrolysis] 2.4-fold and 3.6-fold, accordingly, and simvastatin and it β-hydroxyacid metabolit [measured use of the chemical test - a liquid chromatography / tandemnaja mass spectrometry] 16-fold and 7-fold, accordingly. In the second research of 16 subjects consumed one glass on 8 ounces of juice of a grapefruit of unique force (all can the frozen concentrate terminated buy zocor online with 3 canisters of water) with a breakfast within 3 consecutive days and a unique dose of 20 mg simvastatin on evening of the third day. This way of juice of a grapefruit has led to greedy increase in plasma concentration (as use of the confirmed test of prohibition of the enzyme differing from used in research first2, it is measured by area at unique concentration of a curve), active and full reduktazy HMG-CoA activity prohibition [both before (for active ingibitorov) and after (for full ingibitorov) the basic hydrolysis] 1.13-fold and 1.18-fold, accordingly, and simvastatin and it β-hydroxyacid metabolit [measured use of the chemical test - a liquid chromatography / tandemnaja mass spectrometry] 1.88-fold and 1.31-fold, accordingly. The effect of quantity of juice of a grapefruit between used in these two researches simvastatin pharmacokinetics has not been studied.
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